Publications
2023
Protocol for the isolation and culture of mouse dorsal root ganglion neurons for imaging applications
Patrick R Smith, Angela Meyer, Sarah Loerch, and Zachary T Campbell
STAR Protocols. November 2023
Full Article
2022
Recent advances and current trends in cryo-Electron microscopy
Marghe Guaita, Scott Watters, and Sarah Loerch Current Opinion in Structural Biology. November 2022
Full Article
In situ single particle classification reveals distinct 60S maturation intermediates in cells
Bronwyn A. Lucas, Kexin Zhang, Sarah Loerch, and Niko Grigorieff elife August 2022
Full Article
A UHM-ULM interface contributes to U2AF2 and SF3B1 association for pre-mRNA splicing
Justin W. Galardi, Victoria N. Bela, Nazish Jeffery, Zueyang He, Eliezra Glasser, Sarah Loerch,
Jermaine L. Jenkins, Mary J. Pulvino, Paul L Boutz, and Clara L. Kielkopf
Journal of Biological Chemistry. August 2022 Full Article
The space between notes: emerging roles for translationally silent ribosomes
Patrick R. Smith, Sapna C. Pandit, Sarah Loerch, Zachary T. Campbell
Trends in Biochemical Sciences. March 2022 Full Article
Small-Molecule Ligands can Inhibit -1 programmed ribosomal frameshifting in a broad spectrum of coronaviruses
Sneha Munshi‡, Krishna Neupane‡, Sandaru M Ileperume, Matthew TJ Halma, Jamie A Kelly,
Clarissa F Halpern, Jonathan D Dinman*, Sarah Loerch*, Michael T Woodside*
(‡, co-first authors, *co-corresponding authors).
Viruses. January, 2022 Full Article
2021
Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance in sensory neurons
Patrick R. Smith*, Sarah Loerch*, Nikesh Kunder, Alexander D. Stanowick, Tzu-Fang Lou, and
Zachary Campbell
(*co-first authors).
Nature Communications. November 2021 Full Article
Small-Molecule Ligands can Inhibit -1 programmed ribosomal frameshifting in a broad spectrum of coronaviruses
Sneha Munshi‡, Krishna Neupane‡, Sandaru M Ileperume, Matthew TJ Halma, Jamie A Kelly,
Clarissa F Halpern, Jonathan D Dinman*, Sarah Loerch*, Michael T Woodside*
(‡, co-first authors, *co-corresponding authors).
BioRxiv. August 2021 Full Article
Intercellular Arc Signalling Regulates Vasodilation
June Bryan De La Pena, Paulino Barragan-Iglesias, Tzu-Fang Lou, Nikesh Prakash, Sarah Loerch,
Tarjani Shukla, Lokesh Basavarajappa, Jane Song, Salim Megat, Jamie Moy, Andi Wanghzou,
Pradipta Ray, Kenneth Hoyt, Oswald Steward, Theodore J Price, Jason D Shepherd,
and Zachary T Campbell.
Journal of Neuroscience. July 2021
2020
Intercellular Arc Signalling Regulates Vasodilation
Paulino Barragan-Iglesias, June Bryan De La Pena, Tzu-Fang Lou, Sarah Loerch, Nikesh Prakash,
Tarjani Shukla, Lokesh Basavarajappa, Jane Song, Salim Megat, Jamie Moy, Andi Wanghzou,
Pradipta Ray, Jason D Shepherd, Kenneth Hoyt,Oswald Steward, Theodore J Price, Zachary T Campbell.
BioRxiv. August 2020 Full Article
mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding
Bao C*, Loerch S*, Ling C, Korostelev AA, Grigorieff N, Ermolenko DN.
(* Co-first authors)
Elife. May 2020
2019
Translational Controls in Pain
Sarah Loerch, June Bryan De La Peña, Jane Song, Joseph J. Pancrazio, Theodore J. Price, and Zachary T. Campbell
The Oxford Handbook of Neuronal Protein Synthesis. October 2019
Full Article
Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids
Liberta, F.*, Loerch, S.*, Rennegarbe, M.* et al.
(Co-first authors)
Nature Communications. August 2019
The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface
Loerch, S., Leach, J., Horner, S. , Maji, D., Jenkins, J., Pulvino, M., and Kielkopf, C.
Journal of Biological Chemistry. February 2019
2016
Unmasking the U2AF homology motif family: a bona fide protein–protein interaction motif in disguise
Sarah Loerch and Clara L. Kielkopf
RNA. December 2016
SF1 Phosphorylation Enhances Specific Binding to U2AF65 and Reduces Binding to 3′-Splice-Site RNA
Rakesh Chatrikhi, Wenhua Wang, Ankit Gupta, Sarah Loerch, Alexandre Maucuer, and Clara Kielkopf
Biophysical Journal. December 2016
2015
Dividing and Conquering the RNA Recognition Motif Family: A Representative Case Based on hnRNP L
Sarah Loerch and Clara Kielkopf
Journal of Molecular Biology. September 2015
2014
Cancer-relevant Splicing Factor CAPERα Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex
Sarah Loerch, Alexandre Maucuer, Valerie Manceau, Michael R. Green, and Clara L. Kielkopf
Journal of Biological Chemistry. May 2014
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Structural Biology
Biochemistry
Biophysics